Question

Which of the following about the directionality of nuclear import is FALSE?
Question 2 options:
Ran-GTP has higher affinity (binding strength) to nuclear import receptors than cargo proteins (that contain a nuclear localization sequence, NLS).
Ran-GTP undergoes GTP hydrolysis (to Ran-GDP+Pi) up arrival in the cytoplasm from the nucleus.
Ran-GEF enzymes are most highly abundant in the cytoplasm.
The asymmetric distribution of Ran-GEF and Ran-GAP enzymes is critical for directional nuclear import.
none of the above (are false) – all the above are true.

Question 10 (1 point)

Question 10 options:

	must have at least 7 different internal signal sequences (aka “start transfer signals”)
	must have no more than 2 different stop transfer sequences
	must have two or more different internal signal sequences (aka “start transfer signals”)
	must have at least three of these transmembrane domains be hydrophilic.
	cannot be inserted into the endoplasmic reticulum membrane