Which of the following would be an effector protein at the end of a signaling pathway?
A transcription factor that blocks the promoter region of a kinase
A cytoskeletal anchor protein that when phosphorylated is localized to the leading edge of a migrating cell to direct movement
A protein that breaks down dietary fat to Acetyl CoA for use in the TCA/Krebs/Citric Acid cycle.
All of the above
----------------------------------------------------------------------------------------------------
Match the following membrane receptor types with their characteristics
- A. B. C. D. Opens in response to ligand binding, turns a chemical signal into an electrical one.
- A. B. C. D. Contains intrinsic GTPase activity
- A. B. C. D. Is a 7 pass transmembrane protein
- A. B. C. D. Associate with enzymes in the cell , such as kinases
- A. B. C. D. Can as a molecular switch through phosphorylation and dephosphorylation
- A. B. C. D. Act as a molecular switch through GTP hydrolysis
- A. B. C. D. 1/3 of all drugs target these
A. Enzyme-Coupled Receptors
B. ion-channel-coupled receptor
C. G-Protein coupled receptor
D. G-protein
--------------------------------------------------------------------------------------------------
Place the following steps of GPCR signaling in order
(A) The active beta gamma subunit is bound by inactive alpha subunits, inactivating beta-gamma
(B) The activated alpha subunit binds target proteins until hydrolysis of the GTP inactivates the subunit
(C) The alpha subunit dissociates from the beta and gamma subunits
(D) GTP binds the alpha subunit of the G-Protein
(E) ligand binds to GPCR
(F)GPCR changes conformation
(G)G Protein is recruited to the activated receptor
(H)GDP is dissociated from G Protein complex
Which of the following would be an effector protein at the end of a signaling pathway?
A transcription factor that blocks the promoter region of a kinase | |||||||||||||||||
A cytoskeletal anchor protein that when phosphorylated is localized to the leading edge of a migrating cell to direct movement | |||||||||||||||||
A protein that breaks down dietary fat to Acetyl CoA for use in the TCA/Krebs/Citric Acid cycle. | |||||||||||||||||
All of the above ---------------------------------------------------------------------------------------------------- Match the following membrane receptor types with their characteristics
|
A. | Enzyme-Coupled Receptors |
B. | ion-channel-coupled receptor |
C. | G-Protein coupled receptor |
D. | G-protein |
--------------------------------------------------------------------------------------------------
Place the following steps of GPCR signaling in order
(A) The active beta gamma subunit is bound by inactive alpha subunits, inactivating beta-gamma
(B) The activated alpha subunit binds target proteins until hydrolysis of the GTP inactivates the subunit
(C) The alpha subunit dissociates from the beta and gamma subunits
(D) GTP binds the alpha subunit of the G-Protein
(E) ligand binds to GPCR
(F)GPCR changes conformation
(G)G Protein is recruited to the activated receptor
(H)GDP is dissociated from G Protein complex