MCD BIO 50 Lecture Notes - Lecture 11: Embryonic Stem Cell, Somatic Cell Nuclear Transfer, Transplant Rejection
Document Summary
Science that freaks people out what we can do about the immunity problem (tissue rejection problem) Have a bank of es cells of different hla holotypes representative of different populations. 1st method use of virus: wait a few weeks, pluripotent stem cells (behave as embryonic stem cell but there source is different, change culture conditions to stimulate cells to differentiate into a variety of cell types. Technology of creating ipscs leaves potentially dangerous artifacts in the cells you create (have a propensity to mutate into cancerous cells) Takes 3-4 weeks just to get to the pluripotent stage, longer for differentiated cell types not quite the holy grail . A clone is a genetic copy of an existing organism. Animals can be cloned by slitting an embryo at an early stage of development. Dolly the rst mammal cloned from somatic cells. A donor cell is taken from a sheep"s udder. Donor nucleus taken from the sheep"s cells.