CHEM 1103 Lecture Notes - Lecture 28: Dna Replication, Chromatin, Mendelian Inheritance

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Lecture 28: dna damage and mutations dilks: dna damage, dna of a cell is repeatedly being damaged by, endogeneous factors(e. g. oxygen radicals, replication errors, exogeneous factors (e. g. environmental exposures) If not repaired correctly, these genomic errors can lead to cell death or be passed along to all daughter cells. Insertions/deletions (indels: a mutation is a variation in the dna sequence that is present at an allele frequency of less than 1% in a population. Block 2: single nucleotide polymorphisms (snps, the most common genetic variants are snps, there are an estimated 10-11 million common snps in human populations (maf. Insertions/deletions (indels: addition or deletion of nucleotide(s, unless the length of an indel is a multiple of 3, it produces a frameshift mutation. Ivacaftor, which helps facilitate the opening of the chloride channel on the cell surface to allow chloride and sodium (salt) to move in and out of the cell.