CHEM 1103 Lecture Notes - Lecture 22: Single-Nucleotide Polymorphism, Point Mutation, Dna Replication

• School: University of Arkansas
• Department: Chemistry
• Course: CHEM 1103
• Professor: Matthew Gerner

Document Summary

Block 2: for example, the imino form of adenine will not base-pair with thimine. If repair mechanisms do not replace the purine nucleotide, a point mutation will occur in the next round of dna replication: deamination reactions, c can change to u via deamination and a tautomeric shift. The resulting u would pair with a (rather than the g that: other sources of damage. Block 2 damage, formed by the radiolysis of water, as well as oxidative stress is known to cause some strand breakage and numerous base modifications (thymine glycol, 5-hydroxymethyluracil, and 8-hydroxyguanine): 8-hydroxydeoxyguanosine levels in urine are used to measure the body"s production of ros. Smoking results in increases of 8-ohdg excretion by as much as 50%: most common uv-induced products, created by energy absorption by double bonds are pyrimidine dimers. Benzo (a) pyrene found in cigarette smoke can be consumed as converted to highly reactive derivatives which can cause adducts of most bases: intercalating agents.