CHEM 1103 Lecture Notes - Lecture 13: Signal Transduction, Cell Membrane, Ion Channel

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Lecture 13: cell signaling, part 2: 3 classes of cell surface receptors. Ion-channel receptors: signal binds conformational change of receptor ion channel opens/closes. Friday, september 7, 2018: nicotinic acetylcholine receptor is involved in the generation of action potential, action potential is perpetuated along the axon via the action of voltage-gated ion channels, signaling cascades are commonly used by cells. G-protein coupled and enzyme-linked receptors usually receive signals and transmit them through complex signaling cascades. Most intracellular signaling molecules are proteins often kinases. Friday, september 7, 2018: gpcrs have broad physiological impact, vision (rhodopsin, taste, smell, autonomic nervous system (andrenergic receptors epinephrine, norepinephrine, behavior and mood (serotonin, dopamine, gaba, glutamate, water balance, bone density. Immune system (chemokines: *over 800 human genes predicted to be gpcrs, activated g proteins disassociate to perform signaling. Friday, september 7, 2018: the g-protein subunit switches itself off by hydrolyzing its bound gtp, target proteins for g-protein subunits are either ion channels or membrane-bound enzymes.