BSCI 353 Lecture Notes - Lecture 6: Resting Potential, Atp Hydrolysis, Electrochemical Gradient

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The electrical model of the cell membrane channels are like resistors. More channels less total resistance if you pile up resistors in parallel, there"s more ways for current to flow through conductance = 1/r: reciprocal of resistance, siemens. How do ions get into neurons? pumps/transporters vs. ion channels: pumps use atp hydrolysis to drive this process, ion transporters change the conformation (driven by atp) pumps vs. channels: pumps use atp. Membrane potential will approach nernst potential (ek) for any cell membrane which is mainly or mostly permeable to k. It is the electrogenic activity, not the sodium potassium pump that causes membrane potential! 4x more potassium inside the cell doesn"t mean it"s really positive because there are anions. Potassium chloride concentration outside axon is gradually increased while measuring the membrane potential of axon don"t add charge just change gradient. Evidence that resting potential is determined by k+ concentration gradient. Membrane potential is not completely det by k+ ions.

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