BIO 12D Lecture Notes - Lecture 24: Cytosol, Globular Protein, Sarcomere
16 Aug 2020
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One muscle ber contains a thousand or more myo brils that occupy most of the intracellular volume, leaving little space for cytosol and organelles. Has two protein chains: a heavy and a light chain. Heavy chain is motor domain and binds and uses atp to create movement; called a myosin atpase. 250 myosin molecules joining to create a thick lament. Thick laments are arranged so that the myosin heads are clustered at each end of the lament, and the central region of the. Actin: a protein that makes up the thin laments of the muscle ber; a globular protein (g-actin);g- actin polymerize to form long chains or. 2 f-actin polymers twist together like a double strand of beads, creating the thin lamentsof the myo bril. Crossbridges: made of myosin are are used to connect the thick and thin laments of the myo bril; form when the myosin heads of thick. Laments bind to actin in the thin laments.
