KINE 2475 Lecture Notes - Lecture 15: Bromocriptine, Team Ldlc.Com, Miglitol

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Alpha-glucosidase inhibitors: acrobose & miglitol taken before meals, tid. Inhibit maltase, isomaltase, sucrase & glucomylase in small intestines delayed breakdown of sucrose & complex carbs. Meglitinides: similar to sulfonylurea, faster onset, shorter duration of action, nateglnide & repaglinide- stimulate insulin secretion from beta-cells of prancreas, reduce ppg & a1c by 0. 8-1, se: weight gain, hypoglycemia, no recommended in ada. Bile acids sequestrants approved for dm2: colesevelam is od medication, colesevelam binds to bile acid in lumen to decrease absorption, a1c efficacy is modest, reduces ldl-c by 12-16%, weight neural, low risk of hypoglycemia. Dopamine agonist: bromocriptine mesylate was approved for dm2, a1c efficacy is modest. Low hypothalamic dopamine levels, decrease sympathetic tone & output. Improves hepatic insulin sensitivity & decrease hepatic glucose output. Lowers a1c by 0. 6: used in dm1 as adjunctive therapy, se: gi, nausea, vomiting, anorexia, dose: dm2- 60mcg; dm1- 15mcg.

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