BIOL 2040 Lecture Notes - Lecture 23: Genomic Imprinting, Glucocorticoid Receptor, Dna Methyltransferase

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19 Apr 2016
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Ungroomed rats show neurotic behaviour; not well adjusted. * in people who commit suicide the gr transcript levels are significantly lower* Glucocorticoid receptor (gr) all cells in brain have these (affected by good parenting) Good parenting increase in transcription (through two mechanisms: grooming(early development) --] dnmt --] gr gene remains unmethylated increased transcription, grooming directly activates gr gene transcription. One gene can be silenced during zygote formation. Some genes in our body can only be expressed when from either paternal or maternal dna. In our genome there is a certain # of imprinted genes. We used to think 30-50 genes were imprinted, now we know approximately 1300 are imprinted. Imprinting is different in male and female germlines. Imprinting always means trancriptionally silencing (mostly through dna. Igf2 (insulin-like growth factor2): one of the best understood. Dwarf mouse = not getting enough igf2 production. Only the allele from the father is expressed for this trait:

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