BIO 1140 Lecture Notes - Lecture 9: Electrochemical Gradient, Sh2 Domain, Membrane Potential

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Receptor activation leads to relaying and amplifying the signal inside the cell. This creates maximum cellular response with minimal ligands. Cortisol is secreted by the adrenal glands; it is involved in stress response and metabolism. Cortisol will bind to specific proteins which will trigger and cytoplasmic activation and it will create a protein which then will go on a transcription that will either turn on or off. Ligand will bind to extracellular never enter the cell. Very important for nervous systems used by many nts. Some are very specific allowing only one ion through and some don"t care and let anything go through. Helps with muscle contraction, released in the synapse. It will get very close and diffuse through synapse and will bind with. Intracellular catalytic domain acts as an enzyme. Initiates a cascade of phosphorylation-dephosphorylation that amplifies the ligand"s impact on target cell. 3 main classes focus on tyrosine kinases receptors. Largest family of enzyme receptors (over 20 types)

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