PHED-4547EL Lecture Notes - Lecture 21: Alcoholic Liver Disease, Hepatic Veins, Portal Vein
27 Apr 2020
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Chapter 21 the liver and biliary system. Largest organ in body, right upper abdominal area, beneath the diaphragm. Portal triad, portal tracts travel together: hepatic artery branches, portal vein, bile ducts, lymphatic vessels. Manifestations: cell necrosis, fatty change, mixed necrosis and fatty change. Common types of liver injury: viral hepatitis, fatty liver, alcoholic liver disease or alcoholic hepatitis, cirrhosis. Transmission: person-to-person contact, fecal contamination of food or water. Self-limited; no chronic carriers; no chronic liver disease. Body forms antibodies that provide immunity once recovered. Prevention: hepatitis a vaccine, hepatitis a immune globulin: given after exposure. Infected persons: hepatitis b surface antigen (hbsag) positive; lack anti-hbs. Immune persons: presence of anti-hbs: 10% become carriers and may develop chronic liver disease. Prevention: hepatitis b vaccine, hepatitis b immune globulin: given after exposure. Antigen antibody test results: hepatitis c virus (hcv) rna: presence of virus in blood and active infection, anti-hcv: infection but does not confer immunity.
