ANHB2214 Lecture Notes - Lecture 2: Type Ii Collagen, Ear Canal, Hyaline Cartilage

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Many components of: upper respiratory tract, articular cartilage, epiphyseal plates of long bones, fetal skeleton, main functions, provides smooth, low friction surfaces in joints, structural support for respiratory tract. Many components of: provides cushioning, tensile strength, resistance to tearing and compression, found in intervertebral discs and other certain joints act as lubricated cushions and shock absorbers preventing damage to adjacent vertebrae from abrasive forces or impacts. Osteoblasts/ osteocytes/ osteoclasts: osteoblasts, originate from mesenchymal stem cells, produce organic components of bone matrix. Matricellular glycoproteins: deposition of the inorganic components of bone also depends on osteoblast activity, bone builders, cuboidal cell, single nucleus. Located on the surfaces of bone matrix: osteoclasts, very large motile cells, bone destroyers, multi-nucleated, essential for matrix resorption during bone growth and remodelling. Large size and multi-nucleated condition of osteoclasts are due to their origin from fusion of bone marrow derived monocytes: both on surface of bone, osteocytes within bone matrix.

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